Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ
Prices from the Ray Peat, PhD: “This new proportion of calcium to phosphate is important; that’s why milk products and parmesan cheese are incredibly beneficial for weight loss, and for stopping gaining weight. If you are not really productive, reduced fat whole milk and you can cheese be more effective, as the extra fat calorie consumption aren’t necessary.”
“The foods highest from inside the phosphate, relative to calcium supplements, was grain, beans, meat, and you may fish. Of several wishing food consist of additional phosphate. Items with a high, safer proportion from calcium so you can phosphate is actually simply leaves, particularly kale, turnip vegetables, and you will beet greens, and lots of fruits, dairy, and you will mozzarella cheese.”
Br J Nutr
“Totally free unsaturated efas turn on the stress hormones, and you may cortisol reduces oxidation regarding sugar and you can turns it to your greasy acids and you can triglycerides. Remaining cortisol and you can stress reasonable is the main point. Staying a top ratio out of calcium so you can phosphate helps contradict the pressure metabolism.” “Current book are proving that an excessive amount of phosphate can increase inflammation, tissue atrophy, calcification regarding arteries, cancer, alzhiemer’s disease, and you may, in general, the fresh processes from ageing.”
2006 September;96(3):545-52. Higher phosphorus consumption exceedingly and you can adversely connect with Ca and you may bone metabolism into the an amount-based trends during the fit young women. Kemi VE, Karkkainen dating in Los Angeles MU, Lamberg-Allardt CJ. Ca and P are each other important nourishment to own bones and so are known to connect with perhaps one of the most essential authorities regarding bones kcalorie burning, parathyroid hormonal (PTH). Too big good P intake, normal regarding Western dieting, would-be deleterious so you’re able to bone from the enhanced PTH hormonal. Couples managed amount-effect scientific studies are on the effects off large P consumption inside son. We examined this new short-title aftereffects of five P dosage into the Ca and limbs metabolic process inside the 14 compliment people, 20-28 yrs old, who were randomized to help you four managed research weeks; therefore per investigation topic offered since her very own manage. P supplement amounts out-of 0 (placebo), 250, 750 otherwise 1500 milligrams had been drawn, divided in to around three dosages in the data date. The dishes served were similar through the for every single research day and you can considering 495 mg P and you may 250 milligrams Ca. This new P dosage impacted brand new solution PTH (S-PTH) during the a dose-situated trend (P=0.0005). You will find a reduction in gel ionized California attention only inside the highest P amount (P=0.004). Brand new marker from bones formation, bone-specific alkaline phosphatase, diminished (P=0.05) in addition to limbs resorption marker, N-critical telopeptide of collagen particular We, increased in reaction towards the P amounts (P=0.05). It controlled amount-response studies indicated that P possess a dosage-built affect S-PTH and you can grows PTH hormonal rather when Ca consumption is actually reduced. Exceptionally highest P consumption negatively affects bones metabolic process of the decreasing limbs development and broadening bones resorption, because indicated from the bone metabolic rate markers.
20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.
